Jack Chen

Molecular Biology & Biochemistry



Genomic organizationGenomic variationsTranscriptional regulationCaenorhabditis elegansTool development

My laboratory is interested in developing bioinformatics programs and genomics (and molecular) tools for understanding genome architecture and expression. In particular, we are interested in characterizing gene structures, transcription factors and regulatory elements, sequence and structural variations, and, more importantly, regulatory mechanisms. Ultimately, we are interested in understanding how genome sequences and their organization (including various modifications) direct development and biological functions. Currently, we primarily use the nematode Caenorhabditis elegans as a model system. Bioinformatics programs and genomics tools, however, are generally readily applicable in all organisms, ranging from bacteria to humans. Current research projects fall into two major categories: (1) Identification and characterization of novel genes, synteny blocks, functional elements, genome variations and genome rearrangements; (2) Transcriptional regulation of genes and gene batteries.

My research group provides an ideal environment for students who have interest in the emerging field of genomics and bioinformatics, an exciting field which is developing essentially everyday. Within this group, students have the opportunity to learn and apply computational skills, as well as advanced genomics and molecular techniques. Check current projects in my laboratory. If you find any one interesting to you, send me a message.